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About the Author Dean R. Appling is the Lester J. Reed Professor of Biochemistry and the Associate Dean for Research and Facilities for the College of Natural Sciences at the University of Texas at Austin, where he has taught and done research for the past 29 years. Dean earned his B.S. in Biology from Texas A&M University (1977) and his Ph.D. in Biochemistry from Vanderbilt University (1981). The Appling laboratory studies the organization and regulation of metabolic pathways in eukaryotes, focusing on folate-mediated one-carbon metabolism. The lab is particularly interested in understanding how one-carbon metabolism is organized in mitochondria, as these organelles are central players in many human diseases. In addition to coauthoring the 4th edition of Biochemistry, a textbook for majors and graduate students, Dean has published over 60 scientific papers and book chapters.   As much fun as writing a textbook might be, Dean would rather be outdoors. He is an avid fisherman and hiker. Recently, Dean and his wife, Maureen, have become entranced by the birds on the Texas coast. They were introduced to bird-watching by coauthor Chris Mathews and his wife Kate–an unintended consequence of writing textbooks!   Spencer J. Anthony-Cahill is a Professor in the Department of Chemistry at Western Washington University (WWU), Bellingham, WA. Spencer earned his B.A. in chemistry from Whitman College, and his Ph.D. in bioorganic chemistry from the University of California, Berkeley. His graduate work, in the laboratory of Peter Schultz, focused on the biosynthetic incorporation of unnatural amino acids into proteins. Spencer was an NIH postdoctoral fellow in the laboratory of Bill DeGrado (then at DuPont Central Research), where he worked on de novo peptide design and the prediction of the tertiary structure of the HLH DNA-binding motif. He then worked for five years as a research scientist in the biotechnology industry, developingrecombinant hemoglobin as a treatment for acute blood loss. In 1997, Spencer decided to pursue his long-standing interest in teaching and moved to WWU, where he is today. In 2012 Spencer was recognized by WWU with the Peter J. Elich Award for Excellence in Teaching. Research in the Anthony—Cahill laboratory is directed at the protein engineering and structural biology of oxygen-binding proteins. The primary focus is on circular permutation of human b-globin as a means of developing a single-chain hemoglobin with desirable therapeutic properties as a blood replacement.   Outside the classroom and laboratory, Spencer is a great fan of the outdoors–especially the North Cascades and southeastern Utah, where he has often backpacked, camped, climbed, and mountain biked. He also plays electric bass (poorly) in a local blues—rock band and teaches Aikido in Bellingham.   Christopher K. Mathews is Distinguished Professor Emeritus of Biochemistry at Oregon State University. He earned his B.A. in chemistry from Reed College (1958) and Ph.D. in biochemistry from the University of Washington (1962). He served on the faculties of Yale University and the University of Arizona from 1963 until 1978, when he moved to Oregon State University as Chair of the Department of Biochemistry and Biophysics, a position he held until 2002. His major research interest is the enzymology and regulation of DNA precursor metabolism and the intracellular coordination between deoxyribonucleotide synthesis and DNA replication. From 1984 to 1985, Dr. Mathews was an Eleanor Roosevelt International Cancer Fellow at the Karolinska Institute in Stockholm, and in 1994—1995 he held the Tage Erlander Guest Professorship at Stockholm University.   Dr. Mathews has published about 185 research papers, book chapters, and reviews dealing with molecular virology, metabolic regulation, nucleotide enzymology, and biochemical genetics. From 1964 until 2012 he was principal investigator on grants from the National Institutes of Health, National Science Foundation, and the Army Research Office. He is the author of Bacteriophage Biochemistry (1971) and coeditor of Bacteriophage T4 (1983) and Structural and Organizational Aspects of Metabolic Regulation (1990). He was lead author of four editions of Biochemistry, a textbook for majors and graduate students. His teaching experience includes undergraduate, graduate, and medical school biochemistry courses. He has backpacked and floated the mountains and rivers, respectively, of Oregon and the Northwest. As an enthusiastic birder he has served as President of the Audubon Society of Corvallis and is President of the Great Basin Society, which operates the Malheur Field Station in eastern Oregon. 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About the Author Gerard J. Tortora is a professor of biology and teaches microbiology, human anatomy, and physiology at Bergen Community College in Paramus, New Jersey. He received his M.A. in Biology from Montclair State College in 1965. He belongs to numerous biology/microbiology organizations, such as the American Society of Microbiology (ASM), Human Anatomy and Physiology Society (HAPS), American Association for the Advancement of Science (AAAS), National Education Association (NEA), New Jersey Educational Association (NJEA), and the Metropolitan Association of College and University Biologists (MACUB). Jerry is the author of a number of biological science textbooks. In 1995, he was selected as one of the finest faculty scholars at Bergen Community College and was named Distinguished Faculty Scholar. In 1996, Jerry received a National Institute for Staff and Organizational Development (NISOD) excellence award from the University of Texas and was selected to represent Bergen Community College in a campaign to increase awareness of the contributions of community colleges to higher education.________________________________________ Berdell R. Funke received his Ph.D., M.S., and B.S. in microbiology from Kansas State University. He has spent his professional years as a professor of microbiology at North Dakota State University. He taught introductory microbiology, including laboratory sections, general microbiology, food microbiology, soil microbiology, clinical parasitology, and pathogenic microbiology. As a research scientist in the Experiment Station at North Dakota State, he has published numerous papers on soil microbiology and food microbiology.________________________________________ Christine L. Case is a registered microbiologist and a professor of microbiology at Skyline College in San Bruno, California, where she has taught for the past 38 years. She received her EdD. in curriculum and instruction from Nova Southeastern University and her M.A. in microbiology from San Francisco State University. She was Director for the Society for Industrial Microbiology (SIM). She received the ASM and California Hayward outstanding educator awards. In addition to teaching, Chris contributes regularly to professional literature, develops innovative educational methodologies, and maintains a personal and professional commitment to conservation and the importance of science in society. Chris is also an avid photographer, and many of her photographs appear in this book. 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About the Author Frederic H. (“Ric”) Martini received his Ph.D. from Cornell University in comparative and functional anatomy for work on the pathophysiology of stress. He is the lead author of nine undergraduate texts on anatomy and physiology or anatomy.  Dr. Martini is currently affiliated with the University of Hawaii at Manoa and has a long-standing bond with the Shoals Marine Laboratory, a joint venture between Cornell University and the University of New Hampshire. Dr. Martini is now a President Emeritus of the Human Anatomy and Physiology Society (HAPS) after serving as President-Elect, President, and Past-President over 2005-2007. Dr. Martini was a member of the HAPS committee that established the course curriculum guides for A&P. Michael J. Timmons received his degrees from Loyola University, Chicago. For more than three decades, he has had a strong commitment to teaching nursing and pre-professional students at Moraine Valley Community College (outside Chicago). In 2005-2006, Professor Timmons was honored with the Professor of the Year Award by Moraine Valley Community College and the Excellence award from the National Institute for Staff and Organizational Development for his outstanding contributions to teaching, leadership, and student learning. He has also been the recipient of the Excellence in Teaching Award by the Illinois Community College Board of Trustees. His areas of interest include biomedical photography, crafting illustration programs, and developing instructional technology learning systems. He is a national and regional presenter at the League for Innovation Conferences on Information Technology for Colleges and Universities and at Human Anatomy and Physiology Society (HAPS) meetings.  Robert B. Tallitsch received his Ph.D. in physiology with an anatomy minor from the university of Wisconsin¿–Madison. Since then, he has been on the biology faculty at Augustana College in Rock Island, Illinois. His teaching responsibilities include Human Anatomy, Neuroanatomy, Histology, and Kinesiology. In seven out of the last nine years, Dr. Tallitsch has been designated as one of a select number of “unofficial teachers of the year” by the graduating seniors at Augustana College. 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About the Author James D. Watson is Chancellor Emeritus at Cold Spring Harbor Laboratory, where he was previously its Director from 1968 to 1993, President from 1994 to 2003, and Chancellor from 2003 to 2007. He spent his undergraduate years at the University of Chicago and received his Ph.D. in 1950 from Indiana University. Between 1950 and 1953, he did postdoctoral research in Copenhagen and Cambridge, England. While at Cambridge, he began the collaboration that resulted in the elucidation of the double-helical structure of DNA in 1953. (For this discovery, Watson, Francis Crick, and Maurice Wilkins were awarded the Nobel Prize in 1962.) Later in 1953, he went to the California Institute of Technology. He moved to Harvard in 1955, where he taught and did research on RNA synthesis and protein synthesis until 1976. He was the first Director of the National Center for Genome Research of the National Institutes of Health from 1989 to 1992. Dr. Watson was sole author of the first, second, and third editions of Molecular Biology of the Gene, and a co-author of the fourth, fifth and sixth editions. These were published in 1965, 1970, 1976, 1987, 2003, and 2007, respectively. He is also a co-author of two other textbooks: Molecular Biology of the Cell and Recombinant DNA, as well as author of the celebrated 1968 memoir, The Double Helix, which in 2012 was listed by the Library Of Congress as one of the 88 books that shaped America.________________________________________ Tania A. Baker is the Head of the Department and Whitehead Professor of Biology at the Massachusetts Institute of Technology, and an Investigator of the Howard Hughes Medical Institute. She received a B.S. in biochemistry from the University of Wisconsin, Madison, and a Ph.D. in biochemistry from Stanford University in 1988. Her graduate research was carried out in the laboratory of Professor Arthur Kornberg and focused on mechanisms of initiation of DNA replication. She did postdoctoral research in the laboratory of Dr. Kiyoshi Mizuuchi at the National Institutes of Health, studying the mechanism and regulation of DNA transposition. Her current research explores mechanisms and regulation of genetic recombination, enzyme-catalyzed protein unfolding, and ATP-dependent protein degradation. Professor Baker received the 2001 Eli Lilly Research Award from the American Society of Microbiology and the 2000 MIT School of Science Teaching Prize for Undergraduate Education and is a fellow of the American Academy of Arts and Sciences since 2004 and was elected to the National Academy of Sciences in 2007. She is co-author (with Arthur Kornberg) of the book DNA Replication, Second Edition.________________________________________ Stephen P. Bell is a Professor of Biology at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. He received B.A. degrees from the Department of Biochemistry, Molecular Biology, and Cell Biology and the Integrated Sciences Program at Northwestern University and a Ph.D. in biochemistry at the University of California, Berkeley in 1991. His graduate research was carried out in the laboratory of Dr. Robert Tjian and focused on eukaryotic transcription. He did postdoctoral research in the laboratory of Dr. Bruce Stillman at Cold Spring Harbor Laboratory, working on the initiation of eukaryotic DNA replication. His current research focuses on the mechanisms controlling the duplication of eukaryotic chromosomes. Professor Bell received the 2001 ASBMB–Schering Plough Scientific Achievement Award, the 1998 Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching at MIT and the 2006 MIT School of Science Teaching Award.________________________________________ Alexander A.F. Gann is the Lita Annenberg Hazen Dean and Professor in the Watson School of Biological Sciences at Cold Spring Harbor Laboratory. He is also a Senior Editor at Cold Spring Harbor Laboratory Press. He received his B.Sc in microbiology from University College London and a Ph.D. in molecular biology from The University of Edinburgh in 1989. His graduate research was carried out in the laboratory of Noreen Murray and focused on DNA recognition by restriction enzymes. He did postdoctoral research in the laboratory of Mark Ptashne at Harvard, working on transcriptional regulation, and that of Jeremy Brockes at the Ludwig Institute of Cancer Research at University College London, where he worked on newt limb regeneration. He was a Lecturer at Lancaster University, U.K., from 1996 to 1999, before moving to Cold Spring Harbor Laboratory. He is co-author (with Mark Ptashne) of the book Genes & Signals (2002), and co-editor (with Jan Witkowski) of The Annotated & Illustrated Double Helix. ________________________________________ Michael Levine is a Professor of Genetics, Genomics and Development at the University of California, Berkeley, and is also Co-Director of the Center for Integrative Genomics. He received his B.A. from the Department of Genetics at University of California, Berkeley, and his Ph.D. with Alan Garen in the Department of Molecular Biophysics and Biochemistry from Yale University in 1981. As a postdoctoral fellow with Walter Gehring and Gerry Rubin from 1982-1984, he studied the molecular genetics of Drosophila development.  Professor Levine's research group currently studies the gene networks responsible for the gastrulation of the Drosophila and Ciona (sea squirt) embryos. He holds the F. Williams Chair in Genetics and Development at University of California, Berkeley. He was awarded the Monsanto Prize in Molecular Biology from the National Academy of Sciences in 1996, and was elected to the American Academy of Arts and Sciences in 1996 and the National Academy of Sciences in 1998.________________________________________ Richard M. Losick is the Maria Moors Cabot Professor of Biology, a Harvard College Professor, and a Howard Hughes Medical Institute Professor in the Faculty of Arts & Sciences at Harvard University. He received his A.B. in chemistry at Princeton University and his Ph.D. in biochemistry at the Massachusetts Institute of Technology. Upon completion of his graduate work, Professor Losick was named a Junior Fellow of the Harvard Society of Fellows when he began his studies on RNA polymerase and the regulation of gene transcription in bacteria. Professor Losick is a past Chairman of the Departments of Cellular and Developmental Biology and Molecular and Cellular Biology at Harvard University. He received the Camille and Henry Dreyfuss Teacher-Scholar Award, is a member of the National Academy of Sciences, a Fellow of the American Academy of Arts and Sciences, a Fellow of the American Association for the Advancement of Science, a Fellow of the American Academy of Microbiology, a member of the American Philosophical Society, and a former Visiting Scholar of the Phi Beta Kappa Society. Professor Losick is the 2007 winner of the Selman A. Waksman Award of the National Academy of Sciences, a 2009 winner of the Canada Gairdner Award, and a 2012 winner of the Louisa Gross Horwitz Prize for Biology or Biochemistry of Columbia University. 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